Ulcerative colitis (UC) diagnosis depends on clinical, endoscopic and radiological evaluation. Fecal calprotectin (FC) is a fecal test used to evaluate local gut inflammation. This study was conducted to determine the relation between level of FC and disease activity assessed by Mayo endoscopic score (MES), also relation between FC and disease extent assessed by cross sectional Magnetic Resonance Enterography (MRE). A total of 20 patients diagnosed with UC were included, age (Mean±SD33. 75±12.36), 60.0% males, 40.0% females, Mayo endoscopic score of disease activity was assessed using Ileocolonoscopy, Fecal calprotectin levels were measured and cross-sectional MRE was evaluated for disease extent. In UC patients, FC level is correlated with disease activity assessed by Mayo Endoscopic Score (MES)(correlation coefficient r= 0.517, P= 0.02) with no significant correlation between measured FC levels and disease extents assessed by MRE (P= 0.810). FC level is correlated with disease activity assessed by MES in UC patients but not related to disease extent assessed by cross sectional imaging MRE.