Use of mesenchymal stem cells in Experimental Ovarian Damage

كلية الطب

جامعة أسيوط

Use of mesenchymal stem cells in Experimental Ovarian Damage

مؤلف البحث
Hanan Fouad, Ibrahim A Albahlol, Hazim A Wahab, Eman H Nadwa, Heba M Galal, Mohamed Abouelkheir, Ahmed E Taha, Abdelkarim G Kamel, Hassan A Abdelmawlla
تاريخ البحث
قسم البحث
قسم الفسيولوجيا الطبية
مجلة البحث
Current Stem Cell Research & Therapy
المشارك في البحث
Heba Mohamed Galal Mohamed
الناشر
Bentham Science Publishers
عدد البحث
Volume 19, Issue 5
موقع البحث
https://scholar.google.com/scholar?oi=bibs&cluster=1539492433798837275&btnI=1&hl=en
سنة البحث
2024
صفحات البحث
Pages 725-734
ملخص البحث

Background

Bisphenol-A (BPA) has a well-proven deleterious effect on the hypothalamicpituitary- gonadal axis.

Objectives

The current study investigated the therapeutic potentials of mesenchymal stem cells (MSCs) in a murine model of BPA-induced ovarian damage.

Methods

Fifty adult female rats were divided into: Group 1; control group, Group IIa, IIb: rats were given oral gavage of BPA (25 and 50 mg/Kg body weight respectively) on a daily basis for 15 days, and Group IIIa, IIIb; rats were intravenously treated with of MSCs (106 cells) after receiving the last dose of BPA as in group II. Plasma and ovarian tissue levels of Malondialdehyde (MDA) and gonadal axis hormones were assessed. Apoptosis was evaluated by TUNNEL assay and by apoptosis markers (FAS, FASL, Caspase 3, SLTM). A histological examination of ovarian tissue was also conducted.

Results

BPA resulted in a significant elevation in plasma …