CD10 is widely expressed in various tumor types and their surrounding cancer associated fibroblasts; and correlate withpoor prognosis. In present study CD10 immunohistochemical expression in stromal fibroblasts surrounding urothelialcarcinoma and its relationship with clinicopathological parameters were investigated.

Patients and Methods

Formalin-fixed paraffin embedded tissue sections from 106 urothelial cancer specimens werestained with CD10 antibody using immunohistochemistry technique. Expression of CD10 in the stromal cells was thenanalysed to evaluate its association with different clinicopathological variables.

Results

Stromal CD10 expression was significantly associated with each of high grade (P<0.001), invasive tumor,advanced stage (P<0.001), squamous differentiation of tumor cells (P=0.02) and papillary architecture (P<0.001). Therewas no significant association between stromal CD10 expression and, and patient age, sex and tumor size.

Conclusion

Increased expression of CD10 in cancer associated fibroblasts was strongly correlated with tumorprogression and invasion