Background
Acute kidney injury (AKI) after a percutaneous coronary intervention (PCI) is a major complexity.
Early AKI diagnosis can help in treating this complication. Neutrophil gelatinase‑associated
lipocalin (NGAL) is a recent marker for the diagnosis of contrast‑induced acute kidney
injury (CI‑AKI). This research targeted to evaluate the early diagnosis of CI‑AKI and predictive
value of NGAL and study the correlation between renal role tests and serum NGAL in cases
with coronary artery disorder.
This research was conducted on 45 cases with coronary artery disorder. Serum NGAL, urea,
and creatinine (SCr) were evaluated. The estimated glomerular‑filtration rate (eGFR) was
measured 2 and 48 h after PCI.
Results
In total, 11 (24.4%) patients had AKI, while 34 (75.6%) patients had no AKI. Serum urea NGAL
was significantly greater in AKI cases either 2 or 48 h after PCI, while SCr was significantly
greater in AKI cases 48 h after PCI. eGFR 48 h after PCI was significantly decreased in AKI
patients. Albumin/creatinine (A/C) ratio was significantly greater in AKI cases. Serum NGAL
2 h after PCI positively correlated with A/C ratio and SCr 48 h after PCI, but is negatively
correlated with eGFR 48 h after PCI. After 2 h, serum levels of NGAL had 90% sensitivity and
55% specificity; after 48 h, they had 81% sensitivity and 61% specificity. SCr after 2 h had
63% sensitivity and 82% specificity, and after 48 h, had 90% sensitivity and 88% specificity.
Conclusion
Serum NGAL can represent a sensitive early predictor biomarker for kidney damage after PCI.