Background

Pemphigus is an immune-mediated bullous skin disorder that can be fatal. It is typified by flaccid blisters and erosions of the skin and mucous membranes. The majority of pemphigus patients develop an immunoglobulin E autoantibody response. Galectin-3 (Gal-3) and soluble CD23 are the two primary components of the immunoglobulin E. It is unclear exactly what role Gal-3 plays in pemphigus disease. One of the vital body fluids that can indicate a person’s illness or normal internal features is saliva. Neither the serum nor salivary Gal-3 roles have been identified in pemphigus.

Objectives

We aimed to measure the serum and salivary levels of Gal-3 in pemphigus patients and to find out if there are any relationships between their levels and the Autoimmune Bullous Skin Disease Intensity Score, which measures disease activity.