Background: Meniere's disease is a chronic illness that produces a triad of symptoms; vertigo, hearing loss and tinnitus, each of which is known to have the potential to impact on quality of life and patients' self-care. Aim: Evaluate the effect of life style and dietary intervention on quality of life and self-care among patients with Meniere's disease. Patients and Method: A quasi-experimental (pre-posttest nonequivalent control group design) was used for a purposive sample of sixty adult patients, diagnosed with Meniere's disease in the Ear, Nose and Throat (ENT) department and outpatient clinics at Assiut University Hospital. Patients were randomly divided into two equal groups (study and control) 30 patients for each. Tools: Tool (I): Demographic and medical background information form, Tool (II): Dizziness Handicap Inventory and Tool (III): Therapeutic self-care measure. Results: The mean age of the study and control groups was (44±9.8, 42.03±10.3) years respectively. There was a statistically significant difference between study and control groups regarding the total QoL scores (60.13±14.55, 57.33±13.58), (35.33±7.62, 47.87±17.62) respectively, pre and post lifestyle and dietary intervention with p. value <0.001**. Also, there was a significant improvement in total mean scores of self –care measure among study group as it increased from 20.1±5.52 on pre-intervention to 42.13±8.52 post. Conclusion: Life style and dietary intervention had a positive effect on improving quality of life and self-care activities among study group patients at 3- month follow up compared to the control group. Recommendations: Healthy lifestyle and dietary modifications should be considered as an initial step for both the prevention and management of Meniere's disease.