Research Department
Research File
Research Journal
Eur.J.Med. Chem.
Research Member
Research Publisher
NULL
Research Rank
1
Research Vol
33.675
Research Website
NULL
Research Year
1998
Research_Pages
675
Research Abstract
A series of identical twin esters 3a-e of metronidazole was synthesized and evaluated as
potential prodrugs with improved physicochemical and pharmacokinetic properties. The
synthesis of the twin esters 3a-e was achieved by interaction of metronidazole with the
respective dicarboxylic acid anhydride or their dichloride. Their structures were verified by
elemental and spectroscopic analyses. The lipophilicity of metronidazole and the prodrugs
3a-e, expressed as Rmvalues, were determined using reversed-phase TLC and revealed
