Co-Application of Corticosterone and Growth Hormone Upregulates NR2B Protein and Increases the NR2B: NR2A Ratio and Synaptic Transmission in the Hippocampus

Faculty of Medicine

Assiut University

Co-Application of Corticosterone and Growth Hormone Upregulates NR2B Protein and Increases the NR2B: NR2A Ratio and Synaptic Transmission in the Hippocampus

Research Authors
Ghada S Mahmoud, Ayman S Amer
Research Department
Department of Medical Physiology
Research Journal
Sultan Qaboos University medical journal
Research Member
Ghada Saad Zaghloul Ahmed Mahmoud
Research Rank
1
Research Vol
14(4)
Research Website
pubmed
Research Year
2014
Research_Pages
e486-e494
Research Abstract

Objectives: This in vitro study aimed to investigate the possible mechanism underlying the
protective effect of growth hormone (GH) on hippocampal function during periods of
heightened glucocorticoid exposure. Methods: This study was conducted between January
and June 2005 at the Joan C. Edwards School of Medicine, Marshall University, in
Huntington, West Virginia, USA. The effects of the co-application of GH and corticosterone
(CORT) were tested at different concentrations on the field excitatory postsynaptic ...