Background: Atopic dermatitis (AD) is a chronic inflammatory skin disorder with an
immunologic basis. It may have negative medical and social impacts on patient and his
family. Objectives: assessment of serum level of vitamin D among children with AD and
determine its association with AD severity using SCORAD index. Study Design: A
case-control study. Patients and Method: Twenty nine patients were in the age group
between 2-12 years with AD have been enrolled in the study. The severity of the
disease was determined by AD scoring system (SCORAD). Thirty controls have been
recruited. Serum levels of 25-hydroxyvitamin D3 [25(OH) D3] have been tested using
commercial automated chemiluminescent microparticle immunoassay (CMIA). Results:
The mean value of Vitamin D in children with AD was much lower than normal value,
and there was a significant difference in the mean values of vitamin D between
children with AD (5.4±1.9ng/mL) and the controls (28.9±2.4ng/mL). Serum 25(OH) D
levels were found to be significantly higher in mild AD (14.6±3.5 ng ng/mL) compared
moderate (5.5±3.1 ng/mL) or severe AD (0.3±0.1 ng/mL), p<0.001. Conclusion:
patients with AD have lower serum vit D levels than normal. Vitamin D deficiency might
be related to the severity of AD