Expression of Ezrin and Intercellular Adhesion Molecule-1 (ICAM-1) in Hepatocellular Carcinoma and Non-Neoplastic Liver Lesions of HCV Positive Patients.

Faculty of Medicine

Assiut University

Expression of Ezrin and Intercellular Adhesion Molecule-1 (ICAM-1) in Hepatocellular Carcinoma and Non-Neoplastic Liver Lesions of HCV Positive Patients.

Research Authors
Mamdouh Mohammed Ali, Nemet Allah Abdel-Fatah Mohammed, Sabah Ahmad M. Fadel, and Dalia Ahmad Hamed El-Sers
Research Department
Department of Pathology
Research Journal
Assiut Med. J.
Research Member
Sabah Ahmad Mohamed Fadel
Research Publisher
assuit
Research Rank
2
Research Vol
. Vol.(39), No. (2)
Research Website
Assiut Med. J.
Research Year
2015
Research_Pages
11-28
Research Abstract

This study was carried out on a total number of 95 specimens obtained from HCV positive patients. They grouped into HCC specimens (47), liver cirrhosis (19), chronic hepatitis C (18), and normal liver (11) specimens. Both ezrin and ICAM-1 IRS were low in normal liver with considerable increase in the mean of ezrin IRS in CHC group, while mean of ICAM-1 IRS was minimally increased. Both ezrin and ICAM-1 IRS showed considerable increase in transition from cirrhosis to HCC (p < 0.05). Ezrin and ICAM-1 were over expressed in HCC, and correlated with elevated serum AFP and vascular invasion. There was positive correlation between ezrin and ICAM-1 staining. It indicates that ezrin may increase the expression of ICAM-1 to promote the development and advancement of HCC