Background: Tuberculosis is a disease with high mortality and morbidity. Pulmonary tuberculosis which is one of the granulomatous diseases has few serological markers for its activity. Case detection and early treatment of positive patients are critical to the control of pulmonary tuberculosis (PTB). Traditionally, diagnosis of tuberculosis depends on smear-culture method which although considered gold standard leaves a lot to be desired. New technology offers the opportunity for rapid alternative techniques for the diagnosis of tuberculosis, some of them may prove to be accurate, species-specific and easily applied, new approaches that may be applicable to the recognition of mycobacteria had emerged as immunoassay of mycobacterial antigens. Immunoassay is cheap, uses stable reagents, does not require sophisticated equipment and can be performed in developing countries. Serum CRP levels may have a role in identifying the advanced and extensive disease patients thereby indirectly helping the health workers to pick up delayed convertors/potential defaulters, so as to guide them to put in extra efforts on these groups, in tuberculosis control programs. Vascular endothelial growth factor (VEGF) is one of the major mediators of angiogenesis and vascular permeability. Intense angiogenesis has been found in active pulmonary tuberculosis lesions. VEGF may be a useful screening marker for active tuberculosis, as a negative result greatly reduces the likelihood of tuberculosis. Objective: to determine the serum levels of C-reactive protein (CRP) and Vascular Endothelial growth Factor (VEGF) in patients with tuberculosis and evaluate the relationship with clinical and radiological findings, and to determine whether active pulmonary tuberculosis is associated with increased serum levels of VEGF compared with inactive tuberculosis and healthy subjects. Method: Serum VEGF levels and CRP of 20 patients with active pulmonary tuberculosis, 20 patients with inactive pulmonary tuberculosis, and 10 healthy subjects were determined. Results: CRP was very highly significant (<0.0001) on comparing both active tuberculous and old tuberculous group with control, VEGF was very highly significant (<0.0001), on comparing active tuberculous group with control and significant (P<0.05) on comparing old tuberculous group with control, comparison of active and old tuberculous groups revealed a very significant (<0.0001) as regard CRP and VEGF. No correlation was found between VEGF and CRP in active TB patients or old TB group. Conclusion: The serum levels of C-reactive protein and Vascular Endothelial growth Factor were elevated in patients with tuberculosis in comparison to control, active pulmonary tuberculosis was associated with increased serum levels of VEGF compared with inactive tuberculosis and healthy subjects. Both CRP and VEGF don't correlate with clinical and radiological findings in tuberculous patients. VEGF and CRP may be a useful screening marker for active tuberculosis.