Sonic hedgehog and androgen signaling in tumor and stromal compartments drives epithelial–mesenchymal transition in prostate cancer

Faculty of Medicine

Assiut University

Sonic hedgehog and androgen signaling in tumor and stromal compartments drives epithelial–mesenchymal transition in prostate cancer

Research Authors
Fukashi Yamamichi, Katsumi Shigemura, Hosny M Behnsawy, Fatma Y Meligy, Wen-Chin Huang, Xiangyan Li, Kunito Yamanaka, Keisuke Hanioka, Hideaki Miyake, Kazushi Tanaka, Masato Kawabata, Toshiro Shirakawa, Masato Fujisawa
Research Department
Department of Histology
Research Journal
Scandinavian journal of urology
Research Member
Fatma Yassine Abd el-motagally Meligy
Research Publisher
Taylor & Francis
Research Rank
1
Research Vol
48-6
Research Website
http://www.tandfonline.com/doi/abs/10.3109/21681805.2014.898336
Research Year
2014
Research_Pages
523-532
Research Abstract

Abstract Objective. Sonic hedgehog (Shh) signaling, androgens and epithelial–
mesenchymal transition (EMT) are related to prostate cancer (PCa) progression. The aim of
this study was to investigate how Shh and androgen [dihydrotestosterone (DHT)] signaling
act in prostate epithelial and stromal compartments and whether this signaling pathway
drives EMT and promotes PCa progression. Material and methods. LNCaP, normal prostate
fibroblast (NPF) and cancer-associated prostate fibroblast (CPF) cells were studied .