Aim:
We investigated the associations between variants in genes coding for enzymes and transporters related to the 6-mercaptopurine pathway and clinical outcomes in pediatric patients with acute lymphoblastic leukemia.
MATERIALS & METHODS:
Statistical association between gender, age and genotypes of selected SNPs, and the risks of hematological toxicity and relapse were investigated using a Cox proportional hazard model in 70 acute lymphoblastic leukemia patients from upper Egypt.
RESULTS:
We found significant associations between ITPA, IMPDH1, SLC29A1, SLC28A2, SLC28A3 and ABCC4 SNPs and one or more of the hematological toxicity manifestations (neutropenia, agranulocytosis and leukopenia); age was significantly related to relapse.
CONCLUSION:
Genetic polymorphisms in enzymes and transporters involved in the 6-mercaptopurine pathway should be considered during its use to avoid hematological toxicity.
Research Department
Research Journal
Pharmacogenomics
Research Member
Research Publisher
Future Medicine LTD
Research Rank
1
Research Vol
Pharmacogenomics. 2015 Aug 3:1-15. [Epub ahead of print]
Research Website
NULL
Research Year
2015
Research_Pages
1-15
Research Abstract
