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Immunomodulatory Effects of Levofloxacin on Patients with Pneumonia in Assiut University Hospitals. THE EGYPTIAN JOURNAL OF IMMUNOLOGY
Vol. 22 (1), 2015 Page: 85-91

Research Authors
1MohamedS.Badari,
1ShereinG.Elgendy,
1AsmaaS.Mohamed,
2Alaa
T.Hassan
Research Journal
EGYPTIAN JOURNAL OF IMMUNOLOGY
Research Publisher
EGYPTIAN JOURNAL OF IMMUNOLOGY
Research Rank
2
Research Vol
Vol. 22 (1),
Research Website
EGYPTIAN JOURNAL OF IMMUNOLOGY
Research Year
2015
Research_Pages
85-91
Research Abstract

Theimmunomodulatory effectsofantibioticscouldinfluencethedegreeofsystemicandlocalresponsestoinfection,soinvestigationoftheirintrinsicinfluenceonthehost’sinflammatoryresponseappearstobeessential.Fluoroquinolonesareknowntoexertmodulatoryactivityonimmuneresponsestomicrobialinfection.Howeverthemechanismofthisimmunmodulationhasnotbeenwellelucidated.Theaimofthework,istoassesstheimmunomodulatoryeffectsofalevofloxacin,throughexaminingitseffectontheconcentrationsoftumornecrosisfactorα(TNF-α)andInterleukin–10(IL-10)inserumofpneumonicpatients.Afterfollowinglocalresearchethicscommitteeapprovalandinformedconsent.Thisstudyincluded
40patientswithdifferenttypesofpneumonia,admittedtodepartmentofChestDiseases,FacultyofMedicine,AssiutUniversityHospitals,Egypt.Also,10healthyvolunteersservedasrandomizedcontrols.Bothpatientsandcontrolsreceivedlevofloxacin(750mgoncedailyfor10days).SerumlevelsofTNF-αandIL-10weremeasuredinpatientsandcontrolbeforeandafterlevofloxacinadministration(750mgoncedailyfor10days)usinghumanTNF–αandIL-10ELISAkitsrespectively.LevofloxacincausedastatisticallysignificantdecreaseinthemeanlevelofTNF-αinbothpatients(20.82±1.31pg/ml)(P<0.009)andcontrolgroup(17.12±0.84pg/ml)(P<0.004).Incontrast,therewasstatisticallysignificantincrease(P<0.000)inthemeanlevelofIL-10inpatients (61.75±2.85pg/ml)whilestatisticallysignificantdecrease(P<0.005)incontrolgroup(28.57±1.37pg/ml).Inconclusion,ourstudydemonstratesthattreatmentwithlevofloxacinaffectsproductionofTNF-αasapro-inflammatorycytokineandIL-10asananti-inflammatorycytokineswhichmayprovide additionalbenefitsintreatmentof respiratorytract infectionsthatare independentofitsantibacterialproperties.