Purpose: We assessed the effect of tamsulosin as an adjunctive therapy after
shock wave lithotripsy for pediatric single renal pelvic stones.
Materials and Methods: A total of 120 children with a unilateral single renal
pelvic stone were included in a prospective randomized, controlled study. All
children were randomized to 2 equal groups. Group 1 received tamsulosin
(0.01 mg/kg once daily) as adjunctive therapy after shock wave lithotripsy in
addition to paracetamol while group 2 received paracetamol only. Stone clearance
was defined as no renal stone fragments or fragments less than 3 mm and
no pelvicalyceal system dilatation.
Results: Our study included 69 boys and 51 girls with a median age of 3.5 years
and a median stone size of 1.2 cm. There was no statistically significant difference
between groups 1 and 2 in stone or patient criteria. Of the children
99 (82.5%) achieved stone clearance after the first session, including 50 in group
1 and 49 in group 2. All children in each group were cleared of stones after
the second session. The overall complication rate was 14.2%. There was no statistically
significant difference between single session stone clearance rates
(p ¼ 0.81) and complications rates (p ¼ 0.432) in either group. On multivariate
analysis using logistic regression smaller stone size (p ¼ 0.016) and radiopaque
stones (p ¼ 0.019) were the only predictors of stone clearance at a single shock
wave lithotripsy session. Tamsulosin therapy did not affect stone clearance
(p ¼ 0.649).
Conclusions: Tamsulosin does not seem to improve renal stone clearance.
Smaller and radiopaque renal stones have more chance of clearance after shock
wave lithotripsy for pediatric single renal pelvic stones.NULL
Research Department
Research Journal
The Journal of Urology
Research Member
Research Publisher
Elsevier
Research Rank
1
Research Vol
195
Research Website
http://www.sciencedirect.com/science/article/pii/S0022534715052350NULL
Research Year
2016
Research_Pages
1:5
Research Abstract