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Evaluation of TNF– α, Nitric Oxide, Lipid Profile, Urea and Creatinine Serum Levels for the Prediction of Preeclampsia

Research Authors
Mohammad Sayyed Bakheet, Mohamed Ismail Seddik, M H Abdelzaher Mohammad Mohammad Abolfotoh, Abdelaziz eldarwesh, Alomairi Mostafa,Maher Abdelshakor
Research Journal
International Journal of Research in Pharmacy and Biosciences
Research Member
Research Publisher
Mohammad Sayyed Bakheet
Research Rank
1
Research Vol
V3● I5● May 2016
Research Website
Volume 3, Issue 5, May 2016, PP 27-36
Research Year
2016
Research_Pages
Volume 3, Issue 5, May 2016, PP 27-36
Research Abstract

ABSTRACT TNF– α directly damages the vascular endothelial cells, reduces regional blood flow, causes occlusion of vessels and increases endothelial permeability. Endothelial cell injury after TNF– α mediated activation of immune system may result in secretion of vasoactive substances and increase in vascular permeability and intravascular coagulation. TNF-α may be involved in the pathogenesis of preeclampsia and may identify the patients who are at high risk of PE and can be a potential marker of the severity of the preeclamptic syndrome. Preeclamptic women had deranged lipid profile due to abnormal lipid metabolism; this alteration of lipid metabolism may play a key role in the development of symptoms of Pre-eclampsia. Furthermore, changes in lipid metabolism may contribute towards the endothelial lesions observed in pre-eclampsia.