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Potassium Concentration in Cardioplegic Solutions in Pediatric Patients Undergoing Tetralogy of Fallot Repair: Impact on Myocardial Protection

Research Authors
Mohamed Ahmed Ali1, Sayed Kaoud Abd-Elshafy, Ahmed Mohammed Mandour, Esam M. Abdalla, Ehab A. Zahran, Mahmoud F. Sherif, Hany A. Elmorabaa, Ayman A. Abou Glalah and Amr M. Sleem
Research Journal
Journal of Anesthesia and Clinical Research
Research Member
Research Publisher
OMICS International
Research Rank
1
Research Vol
Volume 9 • Issue 8
Research Website
NULL
Research Year
2018
Research_Pages
7
Research Abstract

Objective: We investigated the cardioprotective effects of two different potassium concentrations in crystalloid
cardioplegic solutions in pediatric patients undergoing tetralogy of Fallot (TOF) repair under cardiopulmonary bypass
(CPB).
Methods: Eighty seven pediatric patients with Tetralogy of Fallot (TOF) were randomly allocated into two groups
according to the type of cardioplegic solution. Group L received large volume with low potassium concentration (K+
10 mmol/L) cardioplegia; 30 ml/kg for induction of arrest and repeated every 20 min at a dose of 15 ml/kg. Group S
received small volume with high potassium concentration (K+ 30 mmol/L) cardioplegia; 10 ml/kg for induction of
arrest and repeated every 20 min at a dose of 5 ml/kg.
Results: Group L showed earlier return of cardiac rhythm (33.8 ± 4.9 sec) compared to 38.9 ± 5.6 sec in group S
with most of the cases had sinus rhythm. The maximum Inotropic Score in the first 24 h was lower in group L; 13 (5)
compared to group S; 15 (10). Less increase in cardiac troponin I (cTnI) in all postoperative readings, shorter
duration of mechanical ventilation, ICU length, and hospital stay in group L. No changes in hemodynamic
parameters between both groups.
Conclusion: Better myocardial protection in pediatric cardiac patients perfused by cardioplegia with low
potassium concentration.