This stud to explore the effect of glycerol on audiovestibular tests in patients with Meniere’s disease (MD)
and to reflect different pathologic states of endolymphatic hydrops (EH) in the inner ear and compare the
results of glycerol on these results.
Subjects: Thirty patients and 15 normal volunteers.
Methods: Each subject of this study underwent pure tone audiometry testing, evoked vestibular evoked
myogenic potential (VEMP) and Vidionystagmography (VNG) before G1 and 2 h after glycerol G2 administration
(1.3 g/kg).
Results: Affected ears were 32 and unaffected ears were 28. The affected ears had higher hearing and SRT
thresholds when compared to the unaffected ears and control group. VEMPs of the affected ears were
normal in six ears (18.75%), absent in four ears (12.5%) and augmented amplitude in 22 (68.75%), their
VNG results showed peripheral vestibular disorder. After oral administration of glycerol, the previous test
battery was repeated and it’s result on PTA showed that 53.13% (17/32) of affected ears had positive glycerol
test mainly in stage II and III. Ten of the 32 affected ears (31.26%) showed improvement of VEMPs
after glycerol administration. Also, two (7.8%) of the unaffected ears showed positive glycerol. Latency
of the VEMP had no significant changes after glycerol administration and there was no statistical correlation
between the results of G-PTA and G-VEMP. There was statistical significant improvement of the
slow peak velocity of caloric test in patient’s affected ears and insignificant improvement in control group
and in unaffected ears after glycerol administration.