Introduction: Excess body weight can result in Diabetes mellitus, where 90% of all diabetics are type 2
(T2DM). Aim of study: To evaluate the effect of Laparoscopic Sleeve Gastrectomy (LSG) as a method of
treatment of type 2 Diabetes mellitus in morbidly obese patients. Patients and methods: A prospective
study was carried out on 40 diabetic morbidly obese patients who underwent LSG during 1.5 years. The
pre-operative diabetic status, duration of Diabetes, body mass index, the excess weight loss percent (EWL
%) at 12 and 18 months follow-up, and remission or improvement of T2DM were recorded and analyzed.
Pre- and postoperative fasting blood glucose, and HbA1C were measured. In addition, Continuous
Glucose Monitoring (CGM) was performed in each patient to clarify the remission of Diabetes. Results:
The mean age of patients was 40.1±4.7 years. The mean preoperative BMI was 51.2±6.5 Kg/m2
. Postoperative calf DVT and bleeding occurred in 5% of cases. Diabetes resolution occurred in 87.5% of
patients (n = 35), where the blood sugar control started at 3 months and reached to no medication at 6
months for 28 patients and 7 patient reached complete cure at 18 months. Diabetes was controlled on oral
hypoglycemic only and a minimal dose was required in 12.5% of patients(n = 5). The EWL% was 70.2% at
12 months and 72.7% at 18 months. Conclusion: LSG resulted in total remission of T2DM in 87.5% of the
patients and easy control of diabetes in 12.5% of patients, and can be considered a metabolic surgery.