Background: Providing the patient with sufficient knowledge about his illness improves the outcomes when delivered properly. Aims: To assess the knowledge and attitude of low-literacy patients undergoing suprapubic catheter insertion. Methods: Study design: Descriptive research design was utilized. Setting: Urology and Nephrology Hospital, Assiut University. Subjects: Eighty patients undergoing suprapubic catheter were selected consecutively within a 12-month period (with maximally primary school educations). Tools: Patient interview questionnaire included 4 parts; parts 1 and 2 to assess demographic and medical data, parts 3 and 4 to assess patients' level of knowledge and attitude. Results: All patients were males with 47.5% of them aged from 50-65 years old. They had poor knowledge about the indications (0%), definition (0%), function (6.3%), procedures of insertion (2.5%) and change (22.5%), receipt of education at the primary care settings (47.5%), ability of self-healthcare (40%), previous experiences (10%) postoperative symptoms (0%) and complications among the studied patients (17.5%) including urine leakage (8.7%) and obstruction (17.5%) of the suprapubic catheter. While most of the patients (95%) reported insufficient healthcare education at the primary settings, all the studied patients wished to have a suitable method for education. There was no statistically significant relation between total knowledge levels and the demographic data. Conclusions: Most of the patients had poor knowledge about the suprapubic catheter and favorable attitudes towards suitable education. Recommendations: Designing a simple method to provide healthcare education for low-literacy patients undergoing suprapubic catheter.