Background and aim: For a long time, the connection between liver cirrhosis (LC) and infections had been studied extensively. Because of their weakened immune system, cirrhotic patients are more likely to contract infectious diseases. Cirrhotic patients are more likely to undergo invasive diagnostic or surgical procedures that can change the host's protective barrier, putting them at a higher risk of contracting an infection. Patients and Methods: The study was conducted over one year duration between January and December 2019 at intensive care unit (ICU). It enrolled all patients with decompensated LC but patients with compensated LC or underlying chronic chest disease were excluded. Baseline evaluation with laboratory data was done in all patients. Blood and sputum cultures were achieved in patients with suspected NCI. Results: 845 patients with LC were admitted to ICU but 345 of them were excluded so, 500 patients were enrolled in the analysis. NCI occurred in 100 (20%) patients. The most frequent isolated organisms were Klebsiella species (32%), Candida albicans (19%), Strept.pneumoniae (12%) and Staph.aureus (10%). All of these infections were in form of pneumoniae. Up to 65% of patients with NCI were died. Based on the current study the predictors of NCI were; old age spontaneous bacterial peritonitis and low serum albumin. Conclusion: Patients with liver cirrhosis are liable to infections secondary to dysregulated immunity. NCI in cirrhotic patients has serious outcome. Hospitalized cirrhotic patients should be screened for NCI.
Research Date
Research Department
Research Journal
Afro-Egyptian Journal of Infectious and Endemic Diseases
Research Member
Research Publisher
Zagazig University, Faculty of Medicine, Endemic and Tropical Medicine Department
Research Year
2021
Research Abstract