Introduction/objectives: Systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) may coexist and carry a higher risk for future comorbidities. Although 14-3-3η protein is recently a known diagnostic marker in rheumatoid arthritis (RA), its role has not been investigated in SLE. The aim of this study was to compare serum 14-3-3η protein level in SLE and RA patients and to examine its association with clinical and laboratory features in SLE patients. Methods: Eighty-four SLE patients and 39 RA patients were included. Sociodemographic, SLE disease activity index (SLEDAI), and damage index were assessed for SLE patients. Data about secondary SS were collected. 14-3-3η was measured by ELISA; titres above 0.19 ng/ml were considered positive. Results: Serum 14-3-3η protein in SLE was significantly lower than in RA (0.37±0.09 vs 1.5±0.51; p < 0.001). 14-3-3η protein level was comparable between …
Research Date
Research Department
Research Journal
Clinical rheumatology
Research Member
Research Vol
39
Research Website
https://web.b.ebscohost.com/ehost/detail/detail?vid=0&sid=0d177bb6-e99d-48c0-9d72-aefadd22cbaf%40pdc-v-sessmgr02&bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d%3d#AN=145109216&db=a9h
Research Year
2020
Research Abstract
