Hypovitaminosis D has a negative impact on the cardiovascular system. We performed the current study to investigate the expression of Vitamin D Receptor (VDR) in atherosclerotic human male aortas and to examine the effect of different doses of Vit. D supplementation on VDR expression in the aortas of male rats fed a High-Fat Diet (HFD). Human participants included 50 atherosclerotic male patients with anterior myocardial infarction and 131 control healthy males. Fifty male Wistar rats were divided into 2 groups: Control (Cont.) group; n = 10 and HFD fed rats; n = 40. The latter was divided equally into 4 subgroups according to the dose of Vit. D supplemented. Vitamin D was supplemented in 3 doses: (0.025, 0.05, 0.075 µg/kg) for a duration of 17 weeks. VDR expression score was immunohistochemically evaluated in aortas of both human and animal study groups. The current study revealed that Vit. D levels were significantly lower in atherosclerotic patients with myocardial infarctions compared to the human control group. Concurrent administration of Vit. D suppresses the progress of atheromatous plaque in rats feed a HFD in a dose-dependent manner. Consequently, it could be concluded that Vit. D supplements are recommended as a prophylaxis in patients at high risk of coronary artery disease.
Research Date
Research Department
Research Journal
American Journal of Biochemistry and Biotechnology
Research Member
Research Publisher
Science publications
Research Vol
17(3)
Research Website
https://doi.org/10.3844/ajbbsp.2021.353.360
Research Year
2021
Research_Pages
353-360
Research Abstract