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Histological Effects of Gestational and Lactational Acrylamide Exposure on the Fundic Mucosa of Adult Albino Rat Offspring and the Possible Ameliorative Role of Quercetin

Research Authors
Mai Emiel Saber, Dorrya Abd-Alla Mohammed Zaghloul, Rasha Ibrahim Anwar, Merry Shenouda
Research Date
Research Department
Research Journal
Egyptian Journal of Histology
Research Year
2022
Research Abstract

الوصف

AbstractBackground: Acrylamide is a toxic chemical used in many industrial uses. It is generated in carbohydrate-rich foods cooked using high temperature. Quercetin is amongst the most effective antioxidant of the flavonoids.

Objective:

To assess the effects of acrylamide on the gastric mucosa in adult male albino rats after maternal exposure to it during pregnancy and lactation and the possible ameliorative role of quercetin.

Materials and Methods:

Twenty-four pregnant albino rats were randomly divided into four equal groups. Group 1: (Control group): kept without treatment. Group 2: (Acrylamide treated group): they received acrylamide in a dose of 30 mg/kg body weight/day Group 3: (Quercetin and acrylamide treated group): they received quercetin in a dose 50 mg/kg body weight/day 2 hours before the acrylamide at the same dose of the previous group. Group 4: (Quercetin treated group): they received