Background:  Corneal refractive surgery for myopia results in an oblate shift with increased postoperative aberrations inversely affecting the quality of vision. Aspheric ablation profiles have been introduced to minimize such a problem. The aim of this study was to compare changes in corneal asphericity, central and mid‑peripheral pachymetry
between the Q‑value customized and the wavefront‑optimized (WFO) ablation profiles.
Methods:  A prospective, comparative non‑randomized fellow eye study was conducted. Eighty eyes of 40 eligible patients underwent femtosecond laser‑assisted laser in situ keratomileusis for myopia and myopic astigmatism. In each patient, the more myopic eye was included in the custom‑Q ablation experimental group and the other less myopic eye was included in the WFO control group. For the custom‑Q group, the target asphericity was set to the preoperative Q‑value. Corneal asphericity, central and mid‑peripheral pachymetric changes and the root mean square of corneal higher‑order aberrations (RMSh) were assessed 6 months following surgery. Visual and refractive outcomes were also evaluated in both platforms 6 months postoperatively.
Results:  The mean preoperative refractive spherical equivalent was significantly more myopic in the custom ‑Q group than in the WFO group (P  =  0.001). The mean Q‑value changed from  −  0.2  ±  0.1 to 0.6  ±  0.7 and from  −  0.2  ±  0.1 to 0.4  ±  0.5 in the custom‑Q and WFO groups, respectively. The oblate shift in corneal asphericity was not significantly different between both treatment groups (P  =  0.094). The mean ablation depth at the pupillary center was signifi‑ cantly greater in the custom‑Q group (P  =  0.011), while there was no significant difference at the mid ‑peripheral pachymetry (P  =  0.256). The RMSh significantly increased in both treatment profiles (P < 0.001) with no significant difference between the two groups (P  =  0.06). The uncorrected distance visual acuity (UDVA) and the manifest refraction spherical equivalents (MRSE) significantly improved in both treatment groups (P < 0.001).
Conclusions:  The custom‑Q treatment profile with target asphericity set at the preoperative Q ‑value achieved com‑ parable outcomes vs. the WFO profile in terms of postoperative corneal asphericity and mid ‑peripheral pachymetry