Study of antibodies to cytolethal distending toxin B (CdtB) and antibodies to vinculin in patients with irritable bowel syndrome

Faculty of Medicine

Assiut University

Study of antibodies to cytolethal distending toxin B (CdtB) and antibodies to vinculin in patients with irritable bowel syndrome

Research Authors
Maysaa El Sayed Zaki, Dina Elhammady, Mona Foda Salama, Mostafa Abdelsalam, Asmaa Osama Bakr Osman
Research Date
Research Department
Department of Clinical Pathology
Research Journal
F1000Research
Research Member
Asso.Asmaa Osama Bakr Seddik Osman
Research Year
2021
Research Abstract

Background: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder, categorized into various subtypes. Post-infection IBS may be attributed to the release of cytolethal distending toxin B (CdtB), which cross-reacts with the adhesion protein vinculin responsible for normal intestinal contractility.

Objective: This study aims to identify anti-CdtB and anti-vinculin levels in IBS patients compared to healthy control.

Subjects and methods: This retrospective case-control study was conducted on 100 subjects with IBS, as determined by a questionnaire based on Rome III criteria, recruited from the outpatient clinics of the Tropical Medicine at Mansoura University Hospital from January 2019 to January 2020.

Results: The optical density (OD) results of the anti-vinculin and anti-CdtB levels were significantly elevated in patients with IBS (1.58±0.496 OD, 2.47±0.60 OD) when compared to control subjects (1.13±0.249 …