Study of single nucleotide polymorphism of vascular endothelium factor in patients with differentiated thyroid cancer

Faculty of Medicine

Assiut University

Study of single nucleotide polymorphism of vascular endothelium factor in patients with differentiated thyroid cancer

Research Authors
Mohamad Mohsen Motawea, Maysaa El Sayed Zaki, Maha Saif, Asmaa Osama BS Osman, Aml Mohamed Nada
Research Date
Research Department
Department of Clinical Pathology
Research Journal
Clinical Diabetes and Endocrinology
Research Member
Asso.Asmaa Osama Bakr Seddik Osman
Research Year
2022
Research Abstract

Background

Genetic alterations and high levels of the vascular endothelial growth factor (VEGF) are presumptive risk factors for differentiated thyroid cancer (DTC).

Objective

This work aims to study the presence of − 634G/C polymorphism of vascular endothelial growth factor (rs2010963) and its’ serum level in patients with DTC and comparing these results with those of the control subjects.

Material and method

The study was a retrograde case–control study that included seventy patients with DTCin addition to seventy apparently healthy control subjects. Blood sample was taken and subjected to study of − 634G/C VEGF polymorphism (rs2010963) by real time PCR and measurement of its’ plasma level by immunoassay kit (ELISA).

Results

Regarding genotyping of VEGFA − 634G/C (rs2010963) polymorphism, there was significant increase in CG and GG genotypes (28.6%, 18.6% respectively) among patients …