Use of mesenchymal stem cells in Experimental Ovarian Damage

Faculty of Medicine

Assiut University

Use of mesenchymal stem cells in Experimental Ovarian Damage

Research Authors
Hanan Fouad, Ibrahim A Albahlol, Hazim A Wahab, Eman H Nadwa, Heba M Galal, Mohamed Abouelkheir, Ahmed E Taha, Abdelkarim G Kamel, Hassan A Abdelmawlla
Research Date
Research Department
Department of Medical Physiology
Research Journal
Current Stem Cell Research & Therapy
Research Member
Heba Mohamed Galal Mohamed
Research Publisher
Bentham Science Publishers
Research Vol
Volume 19, Issue 5
Research Website
https://scholar.google.com/scholar?oi=bibs&cluster=1539492433798837275&btnI=1&hl=en
Research Year
2024
Research_Pages
Pages 725-734
Research Abstract

Background

Bisphenol-A (BPA) has a well-proven deleterious effect on the hypothalamicpituitary- gonadal axis.

Objectives

The current study investigated the therapeutic potentials of mesenchymal stem cells (MSCs) in a murine model of BPA-induced ovarian damage.

Methods

Fifty adult female rats were divided into: Group 1; control group, Group IIa, IIb: rats were given oral gavage of BPA (25 and 50 mg/Kg body weight respectively) on a daily basis for 15 days, and Group IIIa, IIIb; rats were intravenously treated with of MSCs (106 cells) after receiving the last dose of BPA as in group II. Plasma and ovarian tissue levels of Malondialdehyde (MDA) and gonadal axis hormones were assessed. Apoptosis was evaluated by TUNNEL assay and by apoptosis markers (FAS, FASL, Caspase 3, SLTM). A histological examination of ovarian tissue was also conducted.

Results

BPA resulted in a significant elevation in plasma …