ABSTRACT
Background/Aims: Cirrhotic cardiomyopathy (CCM) is defined as an abnormal heart structure and function
in cirrhotic patients. CCM includes systolic and diastolic dysfunction, electrophysiological abnormalities, and
structural changes, both microscopic and macroscopic. Currently, there is no one diagnostic test that can identify
patients with CCM. Evaluation of the validity of galactin-3 and brain natriuretic peptide (BNP) as biomarkers
in the early detection of CCM in comparison to conventional echocardiography.
Materials and Methods: A case control study was carried out in the Departments of internal medicine and
tropical Medicine, Assuit University, Egypt. Seventy-one subjects were divided into the following three groups:
26 cirrhotic patients without ascites, 25 cirrhotic patients with ascites, and 20 healthy controls. All groups underwent
clinical examination, and laboratory investigation including BNP, galactin-3, and echocardiography.
Results: There was a significant difference between the three groups (p<0.001) with regard to corrected QT
(cQT), BNP and galactin-3. Left ventricular diastolic dysfunction with different grades was the most recorded
cardiac abnormality in the patient group I and II (88.5% and 96%; respectively) with significantly increased frequency
and severity in ascetic patients and with the advancement of liver cirrhosis. BNP and galactin-3 were
sensitive and specific biomarkers for the detection of diastolic dysfunction in cirrhotic patients (77.6%, 95.5%,
89.9% and 86.4%; respectively).
Conclusion: Diastolic dysfunction is a common cardiac abnormality in cirrhotic patients that worsens with the
advancement of cirrhosis. BNP and galactin-3 had higher sensitivity and specificity in the early detection of
CCM compared with those of conventional echocardiography.
Keywords: Liver cirrhosis, cardiomyopathy, ascites, cardiac function, BNP, galactin-3