To what extent AstraZeneca ChAdOx1 nCoV-19 vaccine is safe and effective? Rapid systematic review

Faculty of Medicine

Assiut University

To what extent AstraZeneca ChAdOx1 nCoV-19 vaccine is safe and effective? Rapid systematic review

Research Authors
Aliae AR Mohamed Hussein, Islam H Ibrahim, Islam A Mahmoud, Marwa Amary, Reem Sayad
Research Date
Research Department
Department of Chest Diseases
Research Member
Aliae Abd Rabou Mohamed Hussein
Research Publisher
Springer
Research Vol
16
Research Website
https://doi.org/10.1186/s43168-021-00109
Research Year
2022
Research Abstract

Until now, there are more than two hundred million confirmed cases of COVID-19 including more than seven million deaths. Clinical trials of all three vaccines authorized for use in the UK (Pfizer–BioNTech, Oxford–AstraZeneca, and Moderna) have reported high vaccine efficacy. This rapid systematic review was initiated because no systematic review had been conducted to determine the safety and efficacy of AstraZeneca ChAdOx1 nCoV-19 vaccine.

Evidence acquisition

A systematic search in the following platforms: PubMed, Google Scholar, Scopus, WOS, and MEDLINE databases for all articles in the English language regarding safety and efficacy of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 was performed. Papers published up to end of June were included.

Evidence synthesis

Out of 477 retrieved articles, fifteen are included. All the selected articles are concerned with evaluation of AstraZeneca ChAdOx1