Although it is widely recognized that telomere dysfunction plays an important role in cancer, the relationship between telomere function and bladder cancer risk is not well defined. In a case–control study of bladder cancer in Egypt, we examined relationships between two telomere features and bladder cancer risk. Telomere fluorescent in situ hybridization was used to measure telomere features using short-term cultured blood lymphocytes. Logistic regression was used to estimate the strength of association between telomere features and the risk of urothelial carcinoma of the bladder. High telomere length variation (TLV) across all chromosomal ends was significantly associated with an increased risk of bladder cancer [adjusted odds ratios (OR) = 2.22, 95% confidence interval (CI) = 1.48–3.35], as was long average telomere length (OR = 3.19, 95% CI = 2.07, 4.91). Further, TLV and average telomere length...
Research Date
Research Department
Research File
Research Journal
Carcinogenesis
Research Member
Research Publisher
Oxford University Press
Research Vol
36
Research Website
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635668/
Research Year
2015/11/1
Research_Pages
1284-1290
Research Abstract