AO Spine Guideline for the Use of Osteobiologics (AOGO) in Anterior Cervical Discectomy and Fusion for Spinal Degenerative Cases

Faculty of Medicine

Assiut University

AO Spine Guideline for the Use of Osteobiologics (AOGO) in Anterior Cervical Discectomy and Fusion for Spinal Degenerative Cases

Research Authors
Hans Jörg Meisel, Amit Jain, Yabin Wu, Christopher T Martin, Juan Pablo Cabrera, Sathish Muthu, Waeel O Hamouda, Ricardo Rodrigues-Pinto, Jacobus J Arts, Arun-Kumar Viswanadha, Gianluca Vadalà, Pieter-Paul A Vergroesen, Stipe Ćorluka, Patrick C Hsieh, And
Research Date
Research Department
Department of Orthopedic Surgery and Traumatology
Research Journal
Global Spine Journal
Research Member
Mohammad Mostafa Mohammad El-Sharkawi
Research Publisher
SAGE Publications
Research Website
https://journals.sagepub.com/doi/full/10.1177/21925682231178204
Research Year
2024
Research_Pages
6-13
Research Abstract

Study design

Guideline

Objectives

To develop an international guideline (AOGO) about the use of osteobiologics in anterior cervical discectomy and fusion (ACDF) for treating degenerative spine conditions.

Methods

The guideline development process was guided by AO Spine Knowledge Forum Degenerative (KF Degen) and followed the Guideline International Network McMaster Guideline Development Checklist. The process involved 73 participants with expertise in degenerative spine diseases and surgery from 22 countries. Fifteen systematic reviews were conducted addressing respective key topics and evidence was collected. The methodologist compiled the evidence into GRADE Evidence-to-Decision frameworks. Guideline panel members judged the outcomes and other criteria and made the final recommendations through consensus.

Results

Five conditional recommendations were created. A conditional …