[HTML] from springer.com Full View Gene expression of programmed cell death ligand-1 (PDL-1) and vitamin D receptor (VDR) with the serum vitamin D3 in lung cancer

[HTML] from springer.com Full View Gene expression of programmed cell death ligand-1 (PDL-1) and vitamin D receptor (VDR) with the serum vitamin D3 in lung cancer

Research Abstract
Background
Lung cancer (LC) is one of the leading causes of death worldwide. Programmed cell death receptor 1 (PD-1) interacts with its ligand (PDL-1) on T cells inhibiting its functioning which may affect the patient's immunological response.
Aim
Investigate if there is a link between smoking and tissue expression of PDL-1 and vitamin D receptor (VDR) in lung cancer patients. In addition, the relation of vitamin D with smoking and these biochemical markers.
Methods
PDL-1 and VDR expressions were evaluated by real-time PCR in 54 lung cancer biopsy samples and 36 controls to prove this hypothesis. Vitamin D levels in the blood were measured using an ELISA.
Results
Expressions of PDL-1 were significantly upregulated in LC patients than in controls. The highest expression was in stage II and in squamous cell carcinoma followed by small cell carcinoma then adenocarcinoma. However, VDR expressions and …
Research Authors
Ragaa HM Salama, Soad MA Faied, Maha ELkholy, Norhan S Abd-Elmawgoud, Tasneem A Alsanory, Aya A Alsanory, Ahmed A Abd-Elmoniem, Mohamed S Abd-Elmawgoud, Hemat A Mahmoud, Abdel-Rahman H Abdel-Qawy, Marwa A Dahpy
Research Date
Research Department
Department of Diagnostic Radiology
Research Journal
The Egyptian Journal of Bronchology
Research Member
Ahmed Alaa E. Abd Elmoniem
Ragaa Hamdy Mohamed Salama
Maha Mohamed Said Ahmed El-Kholy
Research Pages
65
Research Publisher
Springer Berlin Heidelberg
Research Vol
16
Research Year
2022