Prevention of accidents among disabled children is particularly important, because injuries suffered by these children tend to be more severe. There is an urgent need to address injury prevention and to improve safety standards for this group. This study aimed to assess knowledge and attitude of caregivers regarding accident prevention among disabled school children in Minia Governorate. Descriptive cross sectional research design was used. This study was conducted at the schools of disabled children in Minia city that serve Minia Governorate, which were Al-Fikria School, Al -Nour School and Al-Amal school. The current study included total coverage sample composed of all caregivers in these schools. Two tools were used included a structured interview questionnaire and attitude rating scale. There were statistically significant differences among caregiver's age, sex, level of education and first aid training in relation to their total score of knowledge about accident prevention. Also there were statistically significant differences among caregiver's education and first aid training in relation to their total score of attitude about accident prevention. The study concluded that more than one fifth of caregivers had poor knowledge, and less than one quarter of them had negative attitude about accident prevention. It recommended that providing preventive, first aid and emergency services related to injury prevention.