The present study aimed to investigate the effect of nursing guidelines on minimizing incidence rate of complications among cardiac catheterization patients. Data were collected from the cardiac catheterization unit at Assiut University Hospital. The study was conducted on 60 adult patients, having the following criteria; age between 20 – 65 years who were randomly assigned into two equal groups (study and control group) 30 patients for each group. The study group received the nursing guidelines, while the control group received routine hospital care. Data were collected through the following tools; Structure interviewing questionnaire, cardiac nursing guidelines based on individualized patient needs assessment and follow up sheet used for assessing complications. Results of this study; the majority of the studied sample were male, married, and more than half of them their age has ranged from (50 to 60 years), less than half of the studied sample were overweight and the incidence of local, respiratory and gastrointestinal complications was much more higher in the control group than in the study group. Conclusion; a highly statistical significant difference was found between both the study and the control group regarding incidence of local complications, pneumonia, gastrointestinal complications, while there was no statistical significant differences regarding circulatory and urinary complications. The study recommended that; a nursing guidelines booklet must be available to be applied for patients undergoing cardiac catheterization to decrease incidence rate of post cardiac catheterization complications.