The importance of knowing what patients’ perceive as caring behaviors is a key element to providing compassionate nursing care. The purpose for this study was to identify medical-surgical patients' perceptions of caring behaviors among nurses in Assiut University Hospital. Method(s): A convenience sample of 100 patients was taken from Medical-Surgical units in Assiut University Hospital and participated in this study by accepting and completing the demographics questionnaire, and the Caring Behavior Assessment (CBA) questionnaire. Results: The findings from this study indicated that all (100%) of the respondents were dissatisfied with all aspects of nursing care they received. The top first six of the CBA items are ranked by patient participants as the most important caring behaviors were belonging to HumanismFaith-HopeSensitive subscale, Human Needs Assistance, and Supportive/Protective/ Corrective Environment subscale. Item analysis of patients’ responses on CBA scale revealed that six out of fourteen least important caring behaviors was belonged to Helping/Trust subscale and TeachingLearning subscale. This study also demonstrated that the patient satisfaction was relevant to the nurses caring behaviors. Conclusions & Recommendations: The study concluded that the age, gender, Marital Status, educational level and Hospitalization Experience variables were factors that influenced on the judgment of hospitalized patients regarding their level of satisfaction with the nursing care. This study also demonstrated that the patient satisfaction was relevant to the nurses caring behaviors. Therefore, creating a caring environment and improving the nurses’ caring behaviors may improve the patient quality of care and that will finally improve the patients’ satisfaction.