Stroke is a leading cause of disability. Aim: the first assess patient’s knowledge and practice regarding musculoskeletal complications resulting from immobility. The second evaluate the effect of applying for an exercise programme on stroke immobilized patients’ knowledge and practice. Patient methods: 60 patients conducted at neurological departments at Assiut University Hospital. . Tools: Data collected by using three tools; Tool Ι: Patient's health needs assessment sheet: part 1; A- included Sociodemographic patient characteristics, B- socio-demographic scale, according to Fahmy and Al-sherbeny (1983), part 2; assessment of the past and present health history, part 3; patient’s Assessment for the musculoskeletal complications, Part 4: Assessment of patient's knowledge and practice regarding musculoskeletal complications resulting from immobility and importance of these exercises, Tool II-Musculoskeletal assessment sheet: Part 1; by Ashworth scale ,1964, Part 2; Scandinavian stroke scale,1991. Results: The incidences of musculoskeletal complications in the study sample were lesser than the control group and having higher mean score knowledge regarding stroke. Conclusions: providing a successful physical exercise programme for stroke patients was much more effective on the outcome of patients than those patients in the control group who received routine hospital care. Also, the mean score level of knowledge of the study group patients in the time of follow-up was higher than the mean score level of knowledge of control group patients who didn’t receive the exercise programme. Recommendations: the exercise programme should be applying early as possible as from at the time of admission to the hospital.