Background: Intravenous (IV) medications pose particular risks because of their greater complexity and the multiple steps required in their preparation, administration and monitoring. The aim of this study was; assess the nursing errors during preparation and administration of intravenous drugs. Research design: Descriptive research design used in this study. Subjects: Non probability (convenience) sample was utilized, consisting of all nurses (30 nurses, 18 nurses in burn unit and 12 nurses in plastic surgery unit). Tools: Self-administered questionnaire sheet designed to assess nurses' knowledge in preparation and administration of intravenous drugs and direct Observational check list sheet designed to assess nurses' practice regarding the preparation and administration of IV drugs. Results: More than half of the studied nurses have good knowledge 53.3% regarding preparation of IV drugs, 50% regarding Administration of IV drugs, more than half of them have adequate practice 60% and there were significant relation between nurses' demographic data and their nursing practice regarding training needs (p=0.042). Conclusion: more than half of the studied nurses have good knowledge and adequate practice. Recommendations The nurses need to continue attending training courses, and increase number of nurses in the units