Background: Transurethral resection of the prostate (TURP) is the gold standard of treatment of benign prostatic hyperplasia (BPH). Aims: To evaluate the effect of pre-operative nursing instructions on the potential post-operative complications after TURP. Methods: Study design: A quasi-experimental research design (study-control) was utilized. Setting: Assiut Urology and Nephrology Hospital, Assiut University. Subjects: Eighty male patients undergoing TURP. Tools: Two tools were utilized for data collections including the following: Tool I: Patient assessment sheet: it contained demographic data, pre-operative clinical data, and assessment of post-operative complications. Tool II: Patient’s knowledge questionnaire.Results: There was no statistical significance deference between study and control groups regarding the demographic and preoperative clinical data. The main preoperative symptom was difficulty of micturition (terminal dribbling and Inability to completely empty the bladder). There were statistically significant differences between both groups regarding the total knowledge and postoperative complications Conclusions: Pre-operative nursing instructions improve patients’ knowledge and reduce the rates of TURP complications Recommendations: Routine use of pre-operative nursing instructions for patients undergoing TURP.