Abstract: Despite technological advances contrast induced nephropathy (CIN) remains responsible for a third of all hospital-acquired acute kidney injury, but considered the agent of choice in cardiac interventional procedures. The aims of this study were to; identify associated risk factors for contrast induced nephropathy and assess patients' knowledge as regard preventative measures for CIN , and  evaluate  the effect of nursing instructions on minimizing CIN, Methods: Research design: a quasi- experimental research design. Setting: The study was conducted in cardiac catheterization unit at El -Orman Heart Hospital of Assiut University. Sample: A purposive sample of hundred male and female adult patients who underwent cardiac catheterization. Tools:  tool (I): Structured Interview Questionnaire Sheet: This included four parts (demographic data, physiologic reactions to contrast, risk factors for development of CIN, and serum creatinine follow-up), Tool (II): Patients' knowledge assessment sheet. Results: showed statistical significant differences between pre and post nursing instruction as regarding patient preventive measures for minimizing CIN after contrast injection. Conclusion: Nursing instructions had a good effect on reducing CIN among patients who underwent cardiac catheterization. Recommendation:  Provide evidence-based prevention strategies to allow nurses assist in the prevention of CIN