Nursing care protocol daily sedation is very important to optimize sedation for patients on
mechanical ventilators, these requires nursing staff is very crucial in this aspect to avoid
complication of sedation and earlier extubation. Aim: This study was aimed to identify effect of
nursing care protocol for daily interruption sedation on mechanical ventilation patients outcome.
Design: a quasi-experimental design. Setting: Carried at ICU at Assiut university hospital. Subjects:
A purposive sample of 70 adults patients. Sample was assigned to two equal groups (study and
control). Tools: Four tools were utilized to collect data of study, tool I: Patient assessment sheet.
Tool II: Interruption and infusion sedation assessment scales tool. Tool III: Intensive Care Delirium
Screening Checklist. Tool IV:patients outcome tool. Results: the present study revealed that there
was a statistical significant differences (P<0.001**) between study and control groups in relation to
sedative complication, Delirium , ICU stay, and Duration of mechanical ventilation. Conclusion:
Patient who received nursing care protocol during daily interruption of sedation leading to improve
outcome and reduce complication. Recommendation: Provide in-service education and training
program for critical care nurses regarding applying daily interruption of sedation and how managed
these patients