Background: Acupressure decreases muscular tension, enhancing blood circulation, makes deep relaxation and improving sleep quality. Aim: to investigate effect of acupressure on sleep quality among patients with acute coronary syndrome (ACS). Design: a quasi-experimental design. Setting: Coronary Care Unit at Assiut University Heart Hospital. Subjects: Convenience sample of 60 male and female adult patients were assigned randomly to two equal groups (30 each). Tools: two tools were utilized to collect study data, Tool I Acute Coronary Syndrome patient assessment Tool II: Modified ST Mary’s Hospital Sleep Questionnaire (SMHSQ). Methods: Researcher assessed homodynamic status of both groups every four hours as base line data and for 3 consecutive days. Then, acupressure was applied for study group between 7:10 PM. On morning, sleep quality was assessed for both groups by using modified (SMHSQ) between 7:8 AM. Results: Finding of this study supported stated research hypotheses with statistical significant difference between study and control groups regarding sleep quality on 1st, 2nd and 3rd nights of intervention (P=0.000**, P= 0.000** and P=0.000**) respectively. Conclusion Acupressure can significantly improve sleep quality of ACS patients. Therefore, Utilization of acupressure as a basic part of care provided to all ACS patients is highly recommended.