Today’s health care providers have been recognized that evidence based practice considered the corner and gold standard for quality and safe patient care. Aims 1) Investigate head nurses' attitudes and perceived barriers to implement EBP, 2) Explore head nurses self-efficacy and supporting factors to adopt EBP. 3) Determine head nurses training needs regarding EBP. Descriptive study design was used, Setting: this study was carried out at Assiut university hospitals. Subject: No.= 123 head nurses. Study Tools; consisted of 1) Personal data sheet 2) Perceptions of EBP questionnaire which developed by Majid, et al. (2011) and modified by the researcher. Results: One third of head nurses had positive attitudes toward EBP. As regard barriers that may hinder EBP about half of head nurses mentioned that resources not enough to implement EBP and lack of administrative support Conclusion: the highest percent score of supporting factor to implement EBP related to adequate time to conduct EBP. Meanwhile Head nurses first need for training is to know what is EBP mean, followed by how to search for evidences Recommendations: based up on results the following recommendation are drown; in-services training for head nurses bout EBP and enhance collaboration between nursing services and nursing education