Background: Patient safety is the core indicator of nursing quality. Nursing competency abilities required for performing one’s role as a nurse with knowledge, attitudes and skills. Aim: The study aimed to determine the effectiveness of educational program for nurses about patient safety values, attitudes and competency. Design: A quasi-experimental design. Setting: Intensive care and emergency units at Main Assiut University Hospital. Study subjects: Nurses working in intensive care and emergency units with experience less than one year (No= 55). Study tools: Data were gathered through four tools namely (1): Personal & job characteristics, (2): Patient Safety Value Questionnaire, (3): Patient Safety Attitudes Questionnaire, and (4): Health Professional Education in Patient Safety Survey Results: There were highly statistically significant differences between pre, post &follow up of the program related to nurses' knowledge about patient safety values, attitudes and competency. Conclusion: There were marked improvements in nurses' knowledge regarding patient safety value, attitude and competence immediately after implementation of the educational program. Recommendation: Implement of patient safety culture in healthcare organization according to policies, guidelines, and protocols.