Background: Using time management techniques can have a big impact on how nurses feel stressed at work in a medical setting. Aim: The study sought to ascertain the relation between the time management skills and nurses' work stress levels. Setting: The current study conducted at El-Eman General Hospital in Assiut city Sample: 250 nurses. Research design: The study employed a descriptive research design. Tools: Two tools of data collection namely, Structured Self-Administered Time Management Assessment Questionnaire and Work Related Stress Questionnaire (WSQ). Results: The highest percentage of nurses have fair time management skills (70%), and two third of nurses have high work related stress levels (67.2%), Conclusion: There are statistically significance negative correlation between work related stress levels and time management skills p≤0.001. Recommendation: Provide training programs for nurses about time management strategies and implement stress resolution techniques.