Personality traits are major effective factors on learning approaches, educational achievements, employer's job satisfaction and quality of care. This study aimed to investigate the compatibility of personality traits with the profession for Faculty of Nursing students at Assiut University. The descriptive research design was used on (307) first year nursing students. A self- administered questionnaire: was used to elicit the needed information. It comprised of the socio-demographic data sheet and Eysenck personality inventory. The main results indicated that the majority were single and their mothers were housewives and more than half aged 18 years old. The dominant personality among female students was neuroticism and extraversion. On the opposite, lie was the dominant personality among male students. Around two thirds of female students' was compatible with the nursing profession, but only one third of male students' was compatible. This study recommended that the Dean of Faculty of Nursing, Assiut university should include this personality test among the nursing entrance admission tests in order to select the best students those compatible with nursing profession. This could improve the quality of patient care.