Communication is an essential component of palliative care; communication difficulties are recognized stress factor among health professionals especially nurses. Aims of the study: This study aimed to investigate the relationship between burnout and self –esteem and evaluate the effectiveness of communication skills training among nurses working in psychiatric hospital at Assiut. The study was carried out at Assiut psychiatric mental health Hospital, Ministry of health. The study sample comprised of 30 nurses (14 males and 16 females), tools of the study: five tools were used for data collection, namely: Sociodemographic Data Structured Interview schedules, Burnout rating scale, Self – esteem inventory, Communication skills checklist (Cs – list), and Educational program evaluation sheet. Results: The main results yielded by the study proved that, the highest percentage among nurses aged from 30 or more than 30 years, females than males, and single, more than ⅔ (73.3%) of the studied group lived in rural area. Recommendation: the study recommended continuous education provided for all working nursing personnel and make nurses updated of new knowledge and technology.