Cognitive–behavioral therapy for psychotic patients refers to a structured and time–limited approach to treat a variety of psychiatric disorders. The main goals are: to treat symptoms, to increase insight level and to reduce distress. Aims of the study: This study aimed to assess insight among psychotic patients, to determine the relationship between insight and nonadhering to medications and to study the effects of cognitive– behavioral therapy on the insight of psychotic patients. The study was carried out in the Psychiatric Mental Health Hospital, Ministry of Health at Assiut Governorate. The study sample comprised 20 schizophrenic patients attending to psychiatric unit within a period of three months from October to December 2011, both sexes and agrees to participate in the study, aged from 18- 55 years for three months. Three tools were used for data collection, namely: Structured Questionnaire data sheet, Schedule for the Assessment of Insight (SAI- E) and Drug Attitude Inventory Scale (DAL- 30). Results: The main results yielded by the study proved that, 50% (10) of the studied group were single and 40 %(8) were married, the majority of studied group were illiterate, the highest percentage of insight was improved after application of cognitive – behavioral program (60%), and the highest percentage of adherence to medication were improved after application of program. Conclusion: cognitive – behavior therapy were effective in improvement level of insight and adherence to medication among psychotic patients. Recommendation: the study recommended to continually follow- up on the results of the study repeatedly reviewed the things of patients.