Background: Nursing is a stressful career; occupational stress is a common occurrence in health professions. Job stressors and low job control have been shown to be risk factors for patient safety and lead to poor job performance including reduced quality of nursing care. This study aimed to identify the impact of work stress on quality of nursing care among nurses at EL-Minia University Hospitals. The study was developed within descriptive approach, and was carried out at EL-Minia and Suzan Mubarak University Hospitals in El-Minia Governorate. Sample & setting: Subjects of the study were all nurses (158) who worked in all general and critical departments at El-Minia University Hospitals, three tools were used for data collection: 1- Demographic data sheet 2- Stress scale 3- Quality of nursing care scale. Results: The findings of the study showed that Less than two thirds of the studied nurses had moderate level of stress; more than two thirds of the studied nurses had severe level of the stress. The majority of the studied subjects had accomplished fair quality grade while one quarter had accomplish poor quality grade. Conclusion: It was concluded that there were an inverse relation between stress level and quality of nursing care. Recommendations: organizing stress management program that focuses on different categories of nurses at all hierarchical levels, and organizing a system for continuing education program for nurses.