Transurethral resection is a procedure in which bladder tumors can be removed. Aim: Assess patients' knowledge about bladder cancer and transurethral resection, design nursing instructions for patients undergoing transurethral resection and evaluate the effect of implementing nursing instructions on patients' outcomes. Setting: The study was carried out in the Urology Hospital at Assuit University Hospital. Subjects: 60 adult male patients (18-65) yrs old. Patients were divided randomly into two equal groups (study and control) 30 patients for each. The study group was received the nursing instructions while the control group was received the routine care. Research design: Aquasi-experimental research design was used here. Data collection tools: I) Prepost structured interview questionnaire. II) Pain numeric rating scale. Results: there was statistically significant difference between the study and control groups on knowledge score, and assessment of complications. Conclusion: there was significant improvement post implementing the nursing instructions among the study group. Recommendation: Instructions should be applied to improve patients' condition in simplified booklet.